Targeting human CD34 hematopoietic stem cells with anti-CD45 anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction
نویسندگان
چکیده
Ting C. Zhao, Andy Tseng, Naohiro Yano, YiTang Tseng, Pamela A. Davol, Randall J. Lee, Lawrence G. Lum, and James F. Padbury Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Medical School at Brown University, Providence, Rhode Island; Department of Research, Roger Williams Medical Center, Providence, Rhode Island; University of California-San Francisco, San Francisco, California; and Karmanos Cancer Institute and Departments of Medicine and Immunology and Microbiology, Wayne State University, Detroit, Michigan
منابع مشابه
Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction.
We have previously shown that targeting human CD34(+) hematopoietic stem cells (HSC) with a bispecific antibody (BiAb) directed against myosin light chain (MLC) increases delivery of cells to the injured hearts and improves cardiac performance in the nude rat. In this study, we have sought to validate our previous observations and to perform more detailed determination of ventricular function i...
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Despite the controversy in mechanism, rodent and clinical studies have demonstrated beneficial effects of stem/progenitor cell therapy after myocardial infarction (MI). In a rat ischaemic reperfusion MI model, we investigated the effects of immunomodification of CD 34(+) cells on heart function and myocardial conduction. Bispecific antibody (BiAb), consisting of an anti-myosin light chain antib...
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Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in vivo cell-mediated tissue repair, imaging and localized enrichment without ce...
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BACKGROUND Definite identification of the cell types and the mechanism relevant to cardiomyogenesis is essential for effective cardiac regenerative medicine. We aimed to identify the cell populations that can generate cardiomyocytes and to clarify whether generation of donor-marker(+) cardiomyocytes requires cell fusion between BM-derived cells and recipient cardiomyocytes. METHODOLOGY/PRINCI...
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تاریخ انتشار 2008